loading page

Low-dose Aspirin for Primary Prevention of Adverse Pregnancy Outcomes in Twin Pregnancies: An Observational Cohort Study Based on Propensity Score Matching
  • +7
  • Ying Ye,
  • Li Wen,
  • Xiyao Liu,
  • Lan Wang,
  • Yamin Liu,
  • Richard Saffery,
  • Mark Kilby,
  • Chao Tong,
  • Hongbo Qi,
  • Philip Baker
Ying Ye
Chongqing Medical University First Affiliated Hospital
Author Profile
Li Wen
Chongqing Medical University First Affiliated Hospital
Author Profile
Xiyao Liu
Chongqing Medical University First Affiliated Hospital
Author Profile
Lan Wang
Chongqing Health Center for Women and Children
Author Profile
Yamin Liu
Chongqing Health Center for Women and Children
Author Profile
Richard Saffery
Murdoch Childrens Research Institute
Author Profile
Mark Kilby
University of Birmingham College of Medical and Dental Sciences
Author Profile
Chao Tong
Chongqing Medical University First Affiliated Hospital
Author Profile
Hongbo Qi
Chongqing Medical University First Affiliated Hospital
Author Profile
Philip Baker
University of Leicester
Author Profile

Abstract

Abstract Objective: We aimed to preliminarily assess whether low-dose aspirin(LDA)is beneficial in preventing preeclampsia in twin pregnancies. Design: An observational cohort study. Setting: Two hospital centers in Chongqing, China. Population: 932 twin-pregnant women. Methods: Among 932 participants, 277 in the First Affiliated Hospital of Chongqing Medical University were routinely treated with aspirin (100mg daily) from 12-16 weeks to 35 weeks of gestational age, while 655 in Chongqing Health Center for Women and Children were not taking aspirin during the whole pregnancy. We followed each subject and the individual details were recorded. Main Outcome Measures: The main outcome was to compare the incidence of preeclampsia in women with or without aspirin intaking. Results: LDA significantly reduced the risk of PE (OR: 0.48, 95% CI: 0.24-0.95, p=0.048) and <34 weeks preterm birth (OR: 0.50, 95% CI: 0.29-0.86, p=0.013), but showed possible benefits to lower the rate of SGA babies (OR: 0.74, 95% CI: 0.55-1.00, p=0.063). Moreover, the risk of postpartum hemorrhage was not increased by LDA (OR: 0.89, 95% CI: 0.35-2.26, p=1.000). Conclusions: Treatment with low-dose aspirin in women pregnant with twins could offer some protection against adverse pregnancy outcomes in the absence of any significantly increased risk of postpartum hemorrhage. Funding: The National Key Research and Development Program of China (2018YFC1002900), and National Natural Science Foundation of China (81520108013, 81771613, 81671488, 81871189). Keywords: Twin pregnancy, low-dose aspirin, preeclampsia, preterm birth, small for gestational age