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A Novel Gene Mutation of PIK3R1EY451delinsD in Breast Cancer with the Resistance to HER2-targeted Therapy
  • Kainan Wang,
  • Xuelu Li,
  • Man Li
Kainan Wang
The Second Hospital of Dalian Medical University
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Xuelu Li
The Second Hospital of Dalian Medical University
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Abstract

Previously, little is known about the relationship between the PIK3R1 mutation status and the resistance to HER2-targeted therapies. Herein, we report a HER2-positive breast cancer patient with PIK3R1EY451delinsD showed resistance to HER2-targeted therapy, and adding everolimus to the treatment of trastuzumab and carboplatin achieved better effect.

Peer review status:IN REVISION

13 Oct 2020Submitted to Clinical Case Reports
16 Oct 2020Assigned to Editor
16 Oct 2020Submission Checks Completed
26 Oct 2020Reviewer(s) Assigned
12 Dec 2020Review(s) Completed, Editorial Evaluation Pending
19 Dec 2020Editorial Decision: Revise Minor