Giant cell hepatitis (GCH) with autoimmune hemolytic anemia (AIHA) is a
rare entity in children. GCH is commonly described in infants.
Vaccination has been incriminated as a trigger of development of AIHA in
infants and children. However, vaccination has not been reported, till
the time of writing the manuscript, to trigger the combination of Giant
cell hepatitis with autoimmune hemolytic anemia. GCH with AIHA is
usually fatal. Immunosuppressive treatment with conventional drugs
offers some temporary response. We, herein, report a case of GCH with
AIHA in a 4-month old male infant, following receipt of oral polio
vaccine (OPV) and intramuscular diphtheria-tetanus-pertussis (DPT)
vaccine. The patient was resistant to standard immunosuppressive
combinations, and rescue therapy with Rituximab was used.