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Systems-level approaches for understanding and engineering of the oleaginous cell factory Yarrowia lipolytica
  • Naghmeh Poorinmohammad,
  • Eduard Kerkhoven
Naghmeh Poorinmohammad
Chalmers University of Technology
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Eduard Kerkhoven
Chalmers University of Technology
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Abstract

Concerns about climate change and the search for renewable energy sources together with the goal of attaining sustainable product manufacturing have boosted the use of microbial platforms to produce fuels and high-value chemicals. In this regard, Y. lipolytica has been known as a promising yeast with potentials in diverse array of biotechnological applications such as being a host for different oleochemicals, organic acid and recombinant protein production. Having a rapidly increasing number of molecular and genetic tools available, Y. lipolytica has been well studied amongst oleaginous yeasts and metabolic engineering has been used to explore its potentials. More recently, with the advancement in systems biotechnology and the implementation of mathematical modeling and high throughput omics data-driven approaches, in-depth understanding of cellular mechanisms of cell factories have been made possible resulting in enhanced rational strain design. In case of Y. lipolytica, these systems-level studies and the related cutting-edge technologies have recently been initiated which is expected to result in enabling the biotechnology sector to rationally engineer Y. lipolytica-based cell factories with favorable production metrics. In this regard, here, we highlight the current status of systems metabolic engineering research and assess the potential of this yeast for future cell factory design development.

Peer review status:ACCEPTED

19 Oct 2020Submitted to Biotechnology and Bioengineering
19 Oct 2020Submission Checks Completed
19 Oct 2020Assigned to Editor
11 Nov 2020Reviewer(s) Assigned
19 Jan 2021Review(s) Completed, Editorial Evaluation Pending
19 Jan 2021Editorial Decision: Revise Major
07 Mar 20211st Revision Received
08 Mar 2021Submission Checks Completed
08 Mar 2021Assigned to Editor
22 Apr 2021Reviewer(s) Assigned
10 Jun 2021Review(s) Completed, Editorial Evaluation Pending
10 Jun 2021Editorial Decision: Accept