Association of Dietary and Lifestyle Inflammation Score with
Objective: We aimed to assess the potential association of dietary (DIS)
and lifestyle inflammation score (LIS) and their joint association
(DLIS) with cardiorespiratory fitness (CRF) in Tehranian adults.
Methods: A total of 265 males and females aged 18-70 years (mean ± SD:
36.9 ± 13.3) were entered in the present cross-sectional study. The DIS
was calculated by the use of data from 18 anti- and pro-inflammatory
dietary components, and the LIS by three non-dietary components
including physical activity, smoking status and general adiposity, with
higher scores indicating a more pro-inflammatory diet and lifestyle,
respectively. The DLIS was calculated by summing the DIS and LIS. CRF
was assessed by the Bruce protocol. The odds ratio (OR) and 95%
confidence interval (CI) of CRF across tertiles of the DIS, LIS, and
DLIS were estimated by logistic regression analysis with considering
age, gender, energy intake, marital and education status and occupation
as confounders. Results: The DLIS ranged from -2.10 to 0.38 (mean ± SD:
-1.25 ± 0.64). In the model that controlled for all variables, the ORs
of CRF for the second and third tertiles of the DLIS as compared to the
first tertile were 0.42 (95%CI: 0.20, 0.90) and 0.12 (95%CI: 0.05,
0.32), respectively (P-trend <0.001). There was strong inverse
association between the LIS and CRF (ORthird vs first tertile: 0.12,
95%CI: 0.05, 0.32). There was no association between DIS and CRF.
Conclusion: Having a more inflammatory lifestyle was strongly inversely
associated CRF. More research is needed to confirm the present findings.