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Could perimenopausal oestrogen prevent breast cancer?
  • +2
  • Isaac Manyonda,
  • Vikram Talaulikar,
  • Roxanna Pirhadi,
  • Dibyesh Banerjee,
  • Joseph Onwude
Isaac Manyonda
St George's University Hospitals NHS Foundation Trust
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Vikram Talaulikar
University College London Hospitals NHS Foundation Trust
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Roxanna Pirhadi
Anglia Ruskin University
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Dibyesh Banerjee
St George's University Hospitals NHS Foundation Trust
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Joseph Onwude
The Chelmsford Private Day Surgery Hospital
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Abstract

Breast cancer is the commonest cancer among women in the western world, accounting for up to 30% of all cancers in women. There is a long-standing controversy about the potential link to hormone replacement therapy (HRT), with large observational studies suggesting that HRT increases the risk, while the Women’s Health Initiative (WHI), a prospective, randomised placebo-controlled trial has reported several times over a period of 20 years that combined (oestrogen and progestogen) HRT increases the risk, while oestrogen-only HRT given to women who have had a prior hysterectomy, is associated with a significantly reduced risk of developing breast cancer.