Abstract
The development of nanobubble technology provides a good means for tumor
diagnosis and treatment. In this review, the research and development
progress of nanobubbles is discussed. On the one hand, they can be used
as a good contrast agent for tumors and effectively visualize the shape
of tumors. On the other hand, due to its good water solubility, high
drug loading rate and stability, it is used for the delivery of
anti-tumor drugs, mainly including oxygen nanobubbles, which can
significantly improve the efficacy of chemotherapeutic drugs through
precise administration and targeted reoxygenation in the hypoxic area of
the tumor; there are also vapor nanobubbles, which are formed by
external forces (such as heat or sound) to induce instantaneous
stimulation of nanoparticles, destroy the structure and release drugs to
achieve therapeutic effects. Nanobubbles can also be used in combination
therapy with other drugs. It is expected that this review will provide
new ideas for tumor applications based on nanobubble technology and
promote the process of tumor treatment.