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phage surface induced modulation of inflammatory responses
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  • Zohreh Safari,
  • Majid Sadeghizadeh,
  • Golareh Asgaritarghi,
  • Hassan Bardania,
  • Dina Sadeghizadeh,
  • Sara Soudi
Zohreh Safari
Tarbiat Modares University Faculty of Biological Sciences
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Majid Sadeghizadeh
Tarbiat Modares University Faculty of Biological Sciences
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Golareh Asgaritarghi
Tarbiat Modares University Faculty of Biological Sciences
Hassan Bardania
Yasuj University of Medical Sciences
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Dina Sadeghizadeh
Tarbiat Modares University Faculty of Biological Sciences
Sara Soudi
Tarbiat Modares University Faculty of Medical Sciences
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Abstract

Chronic inflammation responses hamper the tissue engineering. immune system has main function in the regeneration and maintenance of all tissue, the immune reaction to an implant begins by the innate immune cells including macrophages which can eventually lead to accept or reject of the implant. to avoid adverse immune reactions, current strategies use of immunomodulatory biomaterials rather than inert materials. The present study aimed to introduce as biomaterial is capable of modulating macrophage responses. Macrophages cultured on top of four surfaces then analysis morphological characteristics, cellular outgrowth and function. In addition, measured the key cytokine/chemokine markers of macrophage polarization in each sample. The results of our study pointed out that phage nano-structure can modulate polarization of macrophages toward anti-inflammatory phenotype over time. In addition, the combination of well-characterized RGD peptide motif embedded in bacteriophages can stimulate macrophages to gain regenerative M2-like phenotype more effectively and it may introduce an Immuno-modulating biomaterial for tissue engineering applications.

Peer review status:POSTED

19 Oct 2020Submitted to Biotechnology and Bioengineering
20 Oct 2020Assigned to Editor
20 Oct 2020Submission Checks Completed