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Why disulfiram is not a panacea?
  • Boris Cvek
Boris Cvek
Palacky University Olomouc
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Abstract

Two recent studies in Nature and Nature Immunology suggest that an old anti-alcoholism drug disulfiram could treat covid-19 and sepsis, respectively [1-2]. In fact, disulfiram is highly reactive compound (creating both S-S bonds with thiols and chelates with metals) which almost does not exist in the body early after ingestion (the anti-alcoholism effect is caused by its metabolites). [3]