Abstract
Abstract Background A Brucella leak occurred at the Lanzhou
Biopharmaceutical Factory in China. As of September 14, 2020, 96
brucella asymptomatic infections have been detected, while little is
known about them due to lack of the follow-up study. Methods To
synthesise the evidence of the effectiveness of asymptomatic brucellosis
infection. Multiple databases Were searched and inclusion Criteria
included participants were newly infected with Brucella, and had a
positive serum agglutination test (SAT≥100),no symptoms, such as fever,
sweating, malaise; Papers were quality assessed used the Cochrane risk
bias tool. Results Meta-analyses were performed for risk difference and
standardised mean difference of all asymptomatic brucellosis infection.
we conducted a meta-analysis of the published literatures. A total of 56
asymptomatic infections were included in, male adults accounted for the
majority of the cases, and both occupational and non-occupational groups
had asymptomatic infection; 20%(95%CI:0%-55%) of subjects had
positive outcomes and the follow up time ranged from 1-12 months in
meta-analysis. Conclusions Meta-analysis suggests that both occupational
and non-occupational groups have asymptomatic infection and male adults
account for the majority and most of the subjects showing positive
outcome exposed to sheep or unpasteurized dairy products. Key words:
Brucellosis, asymptomatic infection, meta-analysis