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Asymptomatic infection outcomes for brucellosis: A meta-analysis
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  • Huixin Yang,
  • Xiangyi Zhang,
  • Jing Hu,
  • Siwen Zhang,
  • Taijun Wang,
  • Mujinyan Li,
  • Fande Li,
  • Shuqi An,
  • Cui Zhang,
  • Qing Zhen
Huixin Yang
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Xiangyi Zhang
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Siwen Zhang
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Taijun Wang
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Mujinyan Li
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Abstract

Abstract Background A Brucella leak occurred at the Lanzhou Biopharmaceutical Factory in China. As of September 14, 2020, 96 brucella asymptomatic infections have been detected, while little is known about them due to lack of the follow-up study. Methods To synthesise the evidence of the effectiveness of asymptomatic brucellosis infection. Multiple databases Were searched and inclusion Criteria included participants were newly infected with Brucella, and had a positive serum agglutination test (SAT≥100),no symptoms, such as fever, sweating, malaise; Papers were quality assessed used the Cochrane risk bias tool. Results Meta-analyses were performed for risk difference and standardised mean difference of all asymptomatic brucellosis infection. we conducted a meta-analysis of the published literatures. A total of 56 asymptomatic infections were included in, male adults accounted for the majority of the cases, and both occupational and non-occupational groups had asymptomatic infection; 20%(95%CI:0%-55%) of subjects had positive outcomes and the follow up time ranged from 1-12 months in meta-analysis. Conclusions Meta-analysis suggests that both occupational and non-occupational groups have asymptomatic infection and male adults account for the majority and most of the subjects showing positive outcome exposed to sheep or unpasteurized dairy products. Key words: Brucellosis, asymptomatic infection, meta-analysis