loading page

Early recovery of lymphocyte count after hematopoietic stem cell transplantation is a potential risk factor for chronic graft-versus-host disease
  • +4
  • Masato Yanagi,
  • Ryoji Kobayashi,
  • Satoru Matsushima,
  • Daiki Hori,
  • Koya Kodama,
  • Daisuke Suzuki,
  • Kunihiko Kobayashi
Masato Yanagi
Sapporo Hokuyu Hospital
Author Profile
Ryoji Kobayashi
Sapporo Hokuyu hospital
Author Profile
Satoru Matsushima
Sapporo Hokuyu Hospital
Author Profile
Daiki Hori
Sapporo Hokuyu hospital
Author Profile
Koya Kodama
Sapporo Hokuyu Hospital
Author Profile
Daisuke Suzuki
Sapporo Hokuyu Hospital
Author Profile
Kunihiko Kobayashi
Sapporo Hokuyu Hospital
Author Profile

Abstract

Few studies have investigated the association between severity of lymphopenia and clinical outcome during chemotherapy or hematopoietic stem cell transplantation (HSCT). We investigated this issue by retrospectively analyzing pediatric patients who received allogeneic-HSCT (allo-HSCT) using a newly developed parameter called the LD-index that combines both the duration and the intensity of lymphopenia. A total of 92 patients underwent allo-HSCT in our hospital from April 2007 to August 2019. The median age at HSCT was 10.3 years (range 0.4 – 28.1). The median LD-index was 9,285 (range 2,217 – 36,064). A significantly high association was observed between the LD-index and the incidence of chronic graft-versus-host disease (GvHD) (p = 0.0045). Analysis of predictive factors for chronic GvHD was carried out using univariate analysis. Lower LD-index, donor source and duration (days) of lymphopenia were found to be significant factors associated with chronic GvHD. Multivariate analysis, however, only identified an association between lower LD-index and increased incidence of chronic GvHD (p = 0.004). In conclusion, the duration and the intensity of lymphopenia after allo-HSCT have an effect on the development of chronic GvHD.