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Respiratory outcomes in the first ten years-of-life in children with gastroschisis: a retrospective cohort study
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  • Osamuyi Asemota,
  • Gabrielle Derraugh,
  • Matthew Levesque,
  • Suyin Lum Min,
  • Shaikh Iqbal ,
  • Robert Balshaw ,
  • Richard Keijzer
Osamuyi Asemota
University of Manitoba Faculty of Health Sciences
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Gabrielle Derraugh
University of Manitoba Faculty of Health Sciences
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Matthew Levesque
University of Manitoba Faculty of Health Sciences
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Suyin Lum Min
University of Manitoba Faculty of Health Sciences
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Shaikh Iqbal
University of Manitoba Faculty of Health Sciences
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Robert Balshaw
University of Manitoba
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Richard Keijzer
University of Manitoba Faculty of Health Sciences
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Abstract

Background Little attention has been given to the long-term respiratory outcomes of children with gastroschisis. The purpose of this study was to determine if gastroschisis survivors have more respiratory illnesses in their first 10 years-of-life compared to age-matched controls. Methods We performed a retrospective cohort study of all gastroschisis children born in Manitoba between 1991-2017. Gastroschisis cases were identified from a clinical database, and a date-of-birth matched control cohort was constructed from a population-based data repository. International Classification of Disease codes were used to compare the risk and frequency of respiratory diagnoses for children with gastroschisis to date-of-birth matched controls from 0-5 years-of-age and 5-10 years-of-age. Results The 0-5 years-of-age analysis included 117 gastroschisis cases and 1205 date-of-birth matched controls; children with gastroschisis had a higher risk of asthma (RR=1.46, 95%CI:1.03,2.55, p=0.029), acute bronchitis/bronchiolitis (RR=1.61, 95%CI:1.27,2.03, p<0.001), pneumonia (RR=1.99, 95%CI:1.45,2.72, p<0.001), viral pneumonia (RR=5.15, 95%CI:1.79,14.81, p=0.007), and pneumonia due to unspecified organism (RR=2.06, 95%CI:1.45,2.92, p<0.001). Gastroschisis children 0-5 years-of-age were also diagnosed more frequently with bronchitis/bronchiolitis (RR=2.14, 95%CI:1.79,2.57, p<0.001) and viral pneumonia (RR=8.10, 95%CI:3.79,17.31, p<0.001). The 5-10 years-of-age analysis included 73 cases and 738 controls; no difference in the risk of respiratory illness was found for gastroschisis cases and controls in this age group. However, gastroschisis cases were more frequently diagnosed with bacterial pneumonia (RR=3.03, 95%CI:1.67,5.51, p<0.001) and influenza (RR=3.03, 95%CI:1.67,5.51, p<0.001). Conclusion Our study shows that children with gastroschisis have an increased risk of asthma and respiratory infections compared to children without gastroschisis, especially in the first 5 years-of-life.

Peer review status:ACCEPTED

24 Oct 2020Submitted to Pediatric Pulmonology
26 Oct 2020Submission Checks Completed
26 Oct 2020Assigned to Editor
08 Nov 2020Reviewer(s) Assigned
21 Dec 2020Review(s) Completed, Editorial Evaluation Pending
22 Dec 2020Editorial Decision: Revise Minor
04 Feb 20211st Revision Received
05 Feb 2021Submission Checks Completed
05 Feb 2021Assigned to Editor
05 Feb 2021Reviewer(s) Assigned
05 Mar 2021Review(s) Completed, Editorial Evaluation Pending
06 Mar 2021Editorial Decision: Accept