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cGAS-STING pathway participates in endometriosis by up-regulating autophagy:Review.
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  • sennan zhu,
  • qiuyu chen,
  • Xinyi Du,
  • Fengming Xu,
  • Zongwen Liang,
  • yu zhao,
  • qiong zhang
sennan zhu
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qiuyu chen
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Fengming Xu
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Zongwen Liang
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qiong zhang
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Abstract

Double-stranded DNA (dsDNA) sensor cyclic-GMP-AMP synthetase (cGAS) and its downstream interferon gene stimulator (STING) act as important immune monitoring media have become a research hotspot. cGAS-STING pathway may play a key role in the occurrence and development of endometriosis by regulating autophagy. The combination of inhibitors targeting cGAS-STING with estrogen or surgery may become a therapeutic approach for endometriosis, and we present a review about the mechanism and physiological function of cGAS-STING pathway, typical autophagy and STING-dependent atypical autophagy, autophagy expression in endometriosis, and a new idea that cGAS-STING may be involved in endometriosis by regulating autophagy.