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OTITIS MEDIA IN CHILDREN: WHICH PHENOTYPES ARE MOST LINKED TO ALLERGY? A SYSTEMATIC REVIEW
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  • Eugenio De Corso,
  • Elena Cantone,
  • Jacopo Galli,
  • VERONICA SECCIA,
  • DANIELA LUCIDI,
  • TIZIANA DI CESARE,
  • GIANCARLO OTTAVIANO,
  • Bruno Sergi,
  • GAETANO PALUDETTI,
  • Anna Fetoni
Eugenio De Corso
Policlinico Universitario Agostino Gemelli
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Elena Cantone
University of Naples Federico II School of Medicine and Surgery
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Jacopo Galli
Università Cattolica del Sacro Cuore Facoltà di Medicina e Chirurgia
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VERONICA SECCIA
Azienda Ospedaliero Universitaria Pisana
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DANIELA LUCIDI
University Hospital Modena
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TIZIANA DI CESARE
University Hospital Agostino Gemelli
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GIANCARLO OTTAVIANO
Università degli Studi di Padova
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Bruno Sergi
Policlinico A Gemelli
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GAETANO PALUDETTI
University Hospital Agostino Gemelli
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Anna Fetoni
Università Cattolica del Sacro Cuore Facoltà di Medicina e Chirurgia
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Abstract

Background: allergic rhinitis is a common childhood disease responsible for a major impact on quality of life and health care resources. Many hypotheses have been proposed to explain the link between allergy and otitis media, although a definitive mechanism has not been identified yet. One of the major critical points is that authors failed in distinguishing among different phenotypes of middle ear inflammation. This review pointed out evidence from the laboratory and clinical experience to link allergy to different phenotypes of otitis media in children. Methods: we performed a systematic review in accordance with the Preferred Reporting Items for Systematic Review and Meta-Analysis (PRISMA) process. Our search yielded 3010 articles that were finally screened. This resulted in 20 publications of which the full texts included for the qualitative analysis based on different phenotypes of otitis media. Results: clinical evidences and analyses of biomarkers suggested that allergy may be linked to some phenotypes of otitis media and, in particular, to otitis media with effusion and acute re-exacerbations in children with middle ear effusion. It was not possible to perform the analysis for allergy and acute and chronic otitis media because of paucity and heterogeneity of data. Conclusion: Allergy should be considered in the diagnostic work up of different phenotypes of otitis media. Clinicians should evaluate prompt and accurate treatment of allergy in improving outcomes, although futures studies are required to increase evidence supporting that anti-allergy treatment may be effective in the recovery and outcome of otitis media with effusion.

Peer review status:Published

24 Oct 2020Submitted to Pediatric Allergy and Immunology
09 Nov 2020Reviewer(s) Assigned
22 Nov 2020Review(s) Completed, Editorial Evaluation Pending
23 Nov 2020Editorial Decision: Revise Major
03 Dec 20201st Revision Received
04 Dec 2020Review(s) Completed, Editorial Evaluation Pending
04 Dec 2020Reviewer(s) Assigned
09 Dec 2020Editorial Decision: Accept
Apr 2021Published in Pediatric Allergy and Immunology volume 32 issue 3 on pages 524-534. 10.1111/pai.13431