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The Evaluation of Myocardial Performance Index in Patients with COVID-19: An Echocardiographic Follow-up Study”
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  • Hakan Kaya,
  • Ramazan Asoğlu,
  • Abdulmecit Afşin,
  • hakan tibilli,
  • Ercan Kurt,
  • Safiye Kafadar,
  • Umut Gülaçtı,
  • Hüseyin Kafadar
Hakan Kaya
Adiyaman University Faculty of Medicine
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Ramazan Asoğlu
Adiyaman Universitesi
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Abdulmecit Afşin
Adiyaman University
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hakan tibilli
Adiyaman University Faculty of Medicine
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Ercan Kurt
Adiyaman University Faculty of Medicine
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Safiye Kafadar
Adiyaman University Faculty of Medicine
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Umut Gülaçtı
Adiyaman University Faculty of Medicine
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Hüseyin Kafadar
Adiyaman University Faculty of Medicine
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Abstract

INTRODUCTION: The epidemic of pneumonia caused by a new coronavirus disease 2019 (COVID-19) rapidly spread all over the world. Pathophisyology of the cardiovascular effects of COVID-19 is still not well known. Myocardial dysfunction may occur in cytokine-based immune reactions. Myocardial performance index (MPI) is a feasible parameter that reflects systolic and diastolic cardiac functions. We aimed to evaluate the MPI in patients with COVID-19. METHODS: The study consisted of 40 patients diagnosed with COVID-19 who had mild pneumonia and did not need intensive care treatment. All patients underwent echocardiographic evaluation. The MPI and laboratory parameters were compared between the acute period of infection and after clinical recovery in patients with COVID-19. RESULTS: Statistically significant higher MPI (0.56±0.09 versus 0.44±0.07, p<0.001), longer isovolumic relaxation time (112.3 ±13.4 versus 91.8±12.1ms, p<0.001), longer deceleration time (182.1 ± 30.6 versus 161.5 ± 43.5ms, p=0.003), shorter ejection time (279.6±20.3 versus 298.8±36.8ms, p<0.001) and higher E/A ratio (1.53±0.7 versus 1.22±0.4, p<0.001), were observed during acute period of infection compared to ones after clinical recovery. Compared with basal values, no significant change in left ventricular (LV) systolic ejection fraction was observed after clinical recovery (60.3 ± 3.2% versus 61.7±2.4%, p>0.05). CONCLUSION: Our study showed that although, LV systolic function appear normal in COVID-19 patients, they have globally reversible LV diastolic dysfunction, based on tissue Doppler derived MPI. This could be due to isolated subclinical diastolic dysfunction. The underlying mechanism and its clinical significance can be established by further studies.

Peer review status:Published

08 Feb 2021Published in European Heart Journal - Cardiovascular Imaging volume 22 issue Supplement_1. 10.1093/ehjci/jeaa356.100