Fludarabine, mitoxantrone and dexamethasone as a treatment for
refractory T-cell large granular lymphocyte leukemia
Abstract
T-cell large granular lymphocyte leukemia (T-LGLL) is a rare clonal
lymphoproliferative disorder. Because of its low incidence rate and few
cases, there is no standard treatment guideline. We report on a case of
T-LGLL with severe anemia [hemoglobin (HGB): 36 g/L]. After 4 months
of treatment with cyclosporine A, the response was suboptimal, and the
patient still had transfusion-dependent anemia (HGB: 47 g/L). After six
cycles of FND (fludarabine, mitoxantrone, dexamethasone) regimen, the
hematological response was complete (HGB: 143 g/L) and the monoclonal
lymphocytes were nonexistent. Therefore, an FND regimen may be an option
for treating refractory T-LGLL.