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Fludarabine, mitoxantrone and dexamethasone as a treatment for refractory T-cell large granular lymphocyte leukemia
  • +2
  • Jing Liu,
  • Lihua Dong,
  • peng Zu,
  • Jingjing Huang,
  • Yufu Li
Jing Liu
Henan Cancer Hospital
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Lihua Dong
Henan Cancer Hospital
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peng Zu
Henan Cancer Hospital
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Jingjing Huang
Henan Cancer Hospital
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Yufu Li
Henan Cancer Hospital
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Abstract

T-cell large granular lymphocyte leukemia (T-LGLL) is a rare clonal lymphoproliferative disorder. Because of its low incidence rate and few cases, there is no standard treatment guideline. We report on a case of T-LGLL with severe anemia [hemoglobin (HGB): 36 g/L]. After 4 months of treatment with cyclosporine A, the response was suboptimal, and the patient still had transfusion-dependent anemia (HGB: 47 g/L). After six cycles of FND (fludarabine, mitoxantrone, dexamethasone) regimen, the hematological response was complete (HGB: 143 g/L) and the monoclonal lymphocytes were nonexistent. Therefore, an FND regimen may be an option for treating refractory T-LGLL.