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Langerhans cell histiocytosis mimicking subcutaneous granuloma annulare: a case report
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  • Pedro Jesus Agón-Banzo,
  • Alba Santamarina-Albertos,
  • Rocio Muñoz-Martínez,
  • Cristina de Hoyos,
  • Pilar Manchado-López,
  • Ana Julia Garcia Malinis
Pedro Jesus Agón-Banzo
Perpetuo Socorro Healthcare Center
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Alba Santamarina-Albertos
Hospital Clinico Universitario de Valladolid
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Rocio Muñoz-Martínez
Hospital Universitario Rey Juan Carlos
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Cristina de Hoyos
Grupo Medicentro, Clinicas Ceta
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Pilar Manchado-López
Hospital Clinico Universitario de Valladolid
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Ana Julia Garcia Malinis
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Abstract

Langerhans cell histiocytosis (LCH) is characterized by a clonal proliferation of bone marrow-derived Langerhans cells; typically seen in infants and children. The different cutaneous clinical presentation can mimic other diseases. We report a 20 months-old boy with three weeks history of lower limbs cutaneous lesions. Initially, the patient was diagnosed as a subcutaneous granuloma annulare but cutaneous biopsy revealed a dermal infiltration with large histiocytes and positive for S100 and CD1a. LCH mimicking a subcutaneous granuloma annulare was finally diagnosed.