loading page

Identifying the ‘Achilles Heel’ of type 1 diabetes
  • +3
  • Manuela Battaglia,
  • Jane Buckner,
  • Megan Levings,
  • Sarah Richardson,
  • F. Susan Wong,
  • T I M Tree
Manuela Battaglia
San Raffaele Hospital
Author Profile
Jane Buckner
Benaroya Research Institute
Author Profile
Megan Levings
BC Children's Hospital Research Institute
Author Profile
Sarah Richardson
University of Exeter Medical School.
Author Profile
F. Susan Wong
Cardiff University School of Medicine
Author Profile
T I M Tree
GKT School of Medicine
Author Profile

Abstract

When Thetis dipped her son Achilles into the River Styx to make him immortal, she held him by the Heel, which was not submerged, and thus created a weak spot that proved deadly for Achilles. Millennia later, Achilles Heel is part of today’s lexicon meaning an area of weakness or a vulnerable spot that causes failure. Also implied is that an Achilles Heel is often missed, forgotten or underappreciated, until it is under attack, and then failure is fatal. Paris killed Achilles with an arrow ‘guided by the Gods’. At the International Congress of the Immunology of Diabetes Society, 2018, five leading experts were asked to present the case for a particular cell/element that could represent the Achilles Heel of T1D. Their arguments are summarized here, to make this case.

Peer review status:Published

28 Oct 2020Submitted to Clinical & Experimental Immunology
29 Oct 2020Submission Checks Completed
29 Oct 2020Assigned to Editor
29 Oct 2020Reviewer(s) Assigned
14 Nov 2020Review(s) Completed, Editorial Evaluation Pending
16 Nov 2020Editorial Decision: Revise Minor
16 Nov 20201st Revision Received
17 Nov 2020Review(s) Completed, Editorial Evaluation Pending
18 Nov 2020Editorial Decision: Accept
22 Feb 2021Published in Clinical & Experimental Immunology. 10.1111/cei.13570