loading page

Peripheral Blood Stem Cell Mobilisation with Pegylated Granulocyte Colony Stimulating Factor in Children
  • +4
  • Dhwanee Thakkar,
  • Aseem Tiwari,
  • Swati Pabbi,
  • Rohit Kapoor,
  • Geet Aggarwal,
  • Neha Rastogi,
  • Satya Yadav
Dhwanee Thakkar
Medanta The Medicity
Author Profile
Aseem Tiwari
Medanta The Medicity
Author Profile
Swati Pabbi
Medanta The Medicity
Author Profile
Rohit Kapoor
Medanta The Medicity
Author Profile
Geet Aggarwal
Medanta The Medicity
Author Profile
Neha Rastogi
Medanta The Medicity
Author Profile
Satya Yadav
Medanta The Medicity
Author Profile

Abstract

Aim:We report here our experience of using pegylated granulocyte colony stimulating factor (peg-GCSF) for peripheral blood stem cell (PBSC) mobilisation in children. Methods: A total of 9 children suffering from high-risk/relapsed solid tumors were mobilised with chemotherapy and peg-GCSF (100 microgram/kg single dose). Mean age was 7.7years (range 2-15 years). Results:The mean time from peg-GCSF administration to PBSC harvest was 9.7 days. Adequate stem cells (median dose 26.9 million/kg) could be harvested in all children by a single apheresis procedure. No major adverse events observed. Conclusion: It is feasible and safe to mobilise PBSC with peg-GCSF in children with cancer.