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The effect of intralymphatic allergen-specific immunotherapy against house dust mite in murine model of allergic rhinitis
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  • Joo Hyun Jung,
  • Min Young Cho,
  • Heung Eog Cha,
  • Kyeong Ah Kim,
  • Seon Tae Kim
Joo Hyun Jung
Gachon University Gil Medical Center
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Min Young Cho
Gachon University Gil Medical Center
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Heung Eog Cha
Gachon University Gil Medical Center
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Kyeong Ah Kim
Gachon University Gil Medical Center
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Seon Tae Kim
Gachon University Gil Medical Center
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Abstract

Allergen-specific immunotherapy (SIT) has emerged as a promising treatment for IgE-mediated allergic diseases. Several recent studies have shown that allergen-specific intralymphatic immunotherapy (ILIT) is a promising alternative for the treatment of patients with allergic rhinitis (AR), providing superior therapeutic efficacy compared with conventional SIT. Nevertheless, a recent study has shown that in patients with grass pollen allergy, ILIT failed to mitigate the nasal symptoms, improve quality-of-life or intradermal test scores, and reduce the requirement for rescue medications, though modulating IgE and IgG4 levels to some extent. Hence, the efficacy of ILIT in AR remains controversial. The aim of this study was to evaluate the efficacy of ILIT against house dust mite (HDM) in a mouse model of AR.