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Thiol -- Disulphide Homeostasis as a Novel Oxidative Stress Marker in Lung Tuberculosis Patient
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  • Elif Demir,
  • Ramazan Giden,
  • Zafer Hasan Ali Sak,
  • Zeliha Demir Giden
Elif Demir
Harran University
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Ramazan Giden
Harran University
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Zafer Hasan Ali Sak
Harran University
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Zeliha Demir Giden
Harran University
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Abstract

ABSTRACT Aims of Study: To compare dynamic thiol/disulfide homeostasis between patients with with lung tuberculosis and healthy controls. Methods: Our study included 50 patients with active lung tuberculosis and 50 healthy controls. Serum thiol/disulfide was measured with a new automated spectrometric method developed by Erel and Neselioglu, and results were compared statistically. Results: We found that native and total thiol levels were significantly decreased in patients with lung tuberculosis, disulfide/native thiol and disulfide/total thiol levels were found to be higher in lung tuberculosis patients when compared with the control group. However, disulfide levels were higher in the control group than in the patient group. Conclusions: Based on the results of this study, it can be said that oxidative stress is closely associated with lung tuberculosis pathogenesis. There is a need for new studies that will show the possible effects of oxidative stress on lung tuberculosis pathogenesis.

Peer review status:ACCEPTED

29 Oct 2020Submitted to International Journal of Clinical Practice
03 Nov 2020Submission Checks Completed
03 Nov 2020Assigned to Editor
09 Nov 2020Reviewer(s) Assigned
11 Nov 2020Review(s) Completed, Editorial Evaluation Pending
27 Nov 20201st Revision Received
28 Nov 2020Submission Checks Completed
28 Nov 2020Assigned to Editor
28 Nov 2020Reviewer(s) Assigned
30 Nov 2020Review(s) Completed, Editorial Evaluation Pending
30 Nov 20202nd Revision Received
01 Dec 2020Assigned to Editor
01 Dec 2020Submission Checks Completed
01 Dec 2020Reviewer(s) Assigned
16 Dec 2020Review(s) Completed, Editorial Evaluation Pending
03 Jan 2021Editorial Decision: Accept