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Central Airway Issues in BPD
  • Erik Hysinger
Erik Hysinger
Cincinnati Children's Hospital Medical Center
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Abstract

While there is a very large focus on the abnormalities of parenchymal lung development and extensive efforts to minimize alveolar damage with “gentle ventilation” and non-invasive respiratory support for neonates with bronchopulmonary dysplasia (BPD), there is relatively little consideration for the implications of central airway disease in this patient population. There are significant changes in the structure and conformation of the central airway during the last half of gestation, and premature birth disrupts this natural developmental process. Arrest of maturation results in a smaller airway that is more compliant, easier to deform, and more susceptible to damage. Consequently, neonates with BPD are prone to developing central airway pathology, particularly for patient that require intubation and positive pressure ventilation. Central airway disease can be divided in dynamic and fixed airway obstruction and results in increased respiratory morbidity in neonates with chronic lung disease of prematurity.

Peer review status:ACCEPTED

03 Nov 2020Submitted to Pediatric Pulmonology
03 Nov 2020Submission Checks Completed
03 Nov 2020Assigned to Editor
10 Nov 2020Reviewer(s) Assigned
03 Dec 2020Review(s) Completed, Editorial Evaluation Pending
05 Dec 2020Editorial Decision: Revise Minor
12 Dec 20201st Revision Received
15 Dec 2020Submission Checks Completed
15 Dec 2020Assigned to Editor
15 Dec 2020Reviewer(s) Assigned
29 Dec 2020Review(s) Completed, Editorial Evaluation Pending
06 Jan 2021Editorial Decision: Revise Minor
28 Feb 20212nd Revision Received
01 Mar 2021Submission Checks Completed
01 Mar 2021Assigned to Editor
01 Mar 2021Reviewer(s) Assigned
03 Mar 2021Review(s) Completed, Editorial Evaluation Pending
06 Mar 2021Editorial Decision: Revise Minor
10 Mar 20213rd Revision Received
15 Mar 2021Submission Checks Completed
15 Mar 2021Assigned to Editor
15 Mar 2021Reviewer(s) Assigned
20 Mar 2021Review(s) Completed, Editorial Evaluation Pending
20 Mar 2021Editorial Decision: Accept