Safety and Effectiveness of Human Stem Cells for Bronchopulmonary
Dysplasia in Preterm Infants: A Systematic Review and Meta-analysis
Abstract
Objective: To evaluate the safety and efficacy of human stem cells for
bronchopulmonary dysplasia in preterm infants. Study design: From
inception to September 2020, the PubMed, Web of Science, Cochrane
Library and CNKI databases as well as ClinicalTrials.gov were searched
for relevant reports. All the clinical trials, case reports, case series
and letters were included. The included results were analyzed by Stata
16.0. Results: There were no statistically significant differences
between the trial and control groups with respect to the number of
deaths (OR [95% CI]: 0.619 [0.089, 4.316]) or bronchopulmonary
dysplasia cases (OR [95% CI]: 1.138[0.040, 32.36]). The
incidences of serious adverse events and dose-limiting toxicities were
not significantly different between the two groups. There was a
significant statistical difference between the trial and control groups
in the mechanical ventilation duration (P<0.05) and duration
of oxygen (P<0.05). Conclusion: The infusion of human cord
blood stem cells into premature infants does not increase the risk of
serious adverse events or death, and this therapy may decrease the
mechanical ventilation duration and duration of oxygen administration.