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A novel marker of systemic inflammation in psoriasis and related comorbidities: Chitotriosidase
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  • Bilal İlanbey,
  • Ömer Faruk Elmas,
  • Eser Yıldırım Sözmen,
  • Ümran Günay,
  • ABDULLAH DEMİRBAŞ
Bilal İlanbey
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Ömer Faruk Elmas
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Eser Yıldırım Sözmen
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Ümran Günay
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ABDULLAH DEMİRBAŞ
Konya Numune Hospital
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Abstract

Background: Chitotriosidase (ChT) is an enzyme secreted by activated macrophages and neutrophils, in response to proinflammatory signals. There is growing evidence indicating that ChT activity reflects systemic inflammatory status. In this study, we aimed to investigate whether serum ChT activity is increased in patients with psoriasis and related comorbidities. Materials and Methods: This study included patients with psoriasis and healthy volunteers. All subjects underwent a laboratory investigation including serum ChT levels, complete blood count, erythrocyte sedimentation rate, C-reactive protein, and serum lipid levels. Results: 25 patients without comorbidity, 28 patients with comorbidity, and 52 healthy subjects were enrolled. The patients group showed statistically significant higher levels of ChT activity (23.5 ± 11.4 μmol / ml / h) compared to the healthy controls (17.5 ± 10.4/ μmol / ml / h) (p=0.015). ChT activity was also statistically significant higher in patients with comorbidity compared to patients without comorbidity (p = 0.042). Conclusions: Our data support the pathogenetic role of inflammatory processes induced by macrophage activation in psoriasis and related comorbidities. We believe that high ChT activity in patients with psoriasis may serve as a clue for the early prediction of possible related comorbidities.