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Long-term outcomes of percutaneous closure of patent ductus arteriosus accompanied with unilateral absence of pulmonary artery
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  • zhiyuan wang,
  • baojing guo,
  • xiaofang wang,
  • yanyan xiao,
  • zhenyu lv,
  • yongmei liang,
  • mei jin
zhiyuan wang
Capital Medical University Affiliated Anzhen Hospital
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baojing guo
Capital Medical University Affiliated Anzhen Hospital
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xiaofang wang
Capital Medical University Affiliated Anzhen Hospital
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yanyan xiao
Capital Medical University Affiliated Anzhen Hospital
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zhenyu lv
Capital Medical University Affiliated Anzhen Hospital
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yongmei liang
Capital Medical University Affiliated Anzhen Hospital
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mei jin
Capital Medical University Affiliated Anzhen Hospital
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Abstract

Objective: This study aimed to evaluate the long-term outcome of patients with PDA associated with UAPA. Methods: Patients diagnosed with PDA associated with UAPA were retrospectively enrolled from January 2005 to June 2019. Clinical data, treatment and follow-up information were evaluated. Results: 11 patients (5 males and 6 females) were diagnosed with PDA associated with UAPA. Percutaneous closure was conducted in 9 patients successfully. The median age was 37 months. The mean diameter of the PDA and occluders were 5.3±1.8mm (range 2-8.1 mm), 11.5±3.9 mm (4-16 mm) respectively. The median in 5 patients with the pulmonary: systemic flow ratio (Qp:Qs) was 1.41(1.28-8.7) and total lung resistance was 12 wood (1.8-13.6) . The mean systolic pulmonary artery pressure was 68.3±19.1mmHg(42-105mmHg). In 5 patients with pre- and post-procedure catheter data, the systolic pulmonary arterial pressure decreased significantly after closure 77.0±20.2 v 58.8±17.5 mmHg (p = 0.024), and so was the mean pulmonary arterial pressure 58.2±14.6 v 39.0±14.1 mmHg (p = 0.18). The pulmonary artery pressure and heart size gradually decreased to normal in 8 patients, and the quality of life was significantly improved. The ratio of lung to systemic circulation pressure in all these patients was less than 0.75. Conclusions: In appropriate patients with PDA associated with UAPA, transcatheter closure of PDA has the potential to improve the pulmonary artery hypertension. The ratio of lung to systemic circulation pressure less than 0.75 may be important reference index for predicting whether the pulmonary artery pressure could be reduced to normal after occlusion.

Peer review status:ACCEPTED

02 Nov 2020Submitted to Journal of Cardiac Surgery
04 Nov 2020Submission Checks Completed
04 Nov 2020Assigned to Editor
06 Nov 2020Reviewer(s) Assigned
08 Dec 2020Review(s) Completed, Editorial Evaluation Pending
08 Dec 2020Editorial Decision: Revise Minor
05 Jan 20211st Revision Received
06 Jan 2021Assigned to Editor
06 Jan 2021Submission Checks Completed
06 Jan 2021Reviewer(s) Assigned
08 Jan 2021Review(s) Completed, Editorial Evaluation Pending
08 Jan 2021Editorial Decision: Revise Major
26 Feb 20212nd Revision Received
26 Feb 2021Submission Checks Completed
26 Feb 2021Assigned to Editor
26 Feb 2021Reviewer(s) Assigned
04 Mar 2021Review(s) Completed, Editorial Evaluation Pending
04 Mar 2021Editorial Decision: Accept