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Late relapse of IgM nephropathy-associated nephrotic syndrome after repeated administration of immune checkpoint inhibitor against pulmonary adenocarcinoma
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  • Kentaro Odani,
  • Mitsuhiro Tachibana,
  • Fumiaki Nogaki,
  • Yutaka Tsutsumi
Kentaro Odani
Shimada Municipal Hospital
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Mitsuhiro Tachibana
Shimada Municipal Hospital
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Fumiaki Nogaki
Shimada Municipal Hospital
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Yutaka Tsutsumi
Pathos Tsutsumi
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Abstract

A man aged 60’s suffered nephrotic syndrome with IgM nephropathy seven years earlier. Four years later, immune-checkpoint inhibitors (ICPIs) were administered against metastasizing pulmonary adenocarcinoma. Sixty-two weeks after 21 ICPIs injections, the cancer vanished but nephrotic syndrome relapsed. Acute pancreatitis followed and usual interstitial pneumonia exacerbated, as late-onset immune-related adverse-events.

Peer review status:Published

05 Nov 2020Submitted to Clinical Case Reports
05 Nov 2020Submission Checks Completed
05 Nov 2020Assigned to Editor
15 Nov 2020Reviewer(s) Assigned
03 Dec 2020Review(s) Completed, Editorial Evaluation Pending
03 Dec 2020Editorial Decision: Revise Minor
07 Jan 20211st Revision Received
08 Jan 2021Submission Checks Completed
08 Jan 2021Assigned to Editor
08 Jan 2021Review(s) Completed, Editorial Evaluation Pending
24 Jan 2021Editorial Decision: Accept
Apr 2021Published in Clinical Case Reports volume 9 issue 4 on pages 1917-1924. 10.1002/ccr3.3903