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EVALI versus MIS-C, one more overlapping diagnosis to consider
  • +5
  • Diego Cruz-Vidal,
  • Eric Mull,
  • Jeannette Taveras,
  • Richard Shell,
  • William Hunt,
  • Brian Fowler,
  • Rebecca Wallihan,
  • Guliz Erdem
Diego Cruz-Vidal
Nationwide Children's Hospital
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Eric Mull
Nationwide Children's Hospital
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Jeannette Taveras
Nationwide Children's Hospital
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Richard Shell
Nationwide Children’s Hospital
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William Hunt
Nationwide Children's Hospital
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Brian Fowler
Nationwide Children's Hospital
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Rebecca Wallihan
Nationwide Children's Hospital
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Guliz Erdem
Nationwide Children's Hospital
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Abstract

We describe six teenagers presenting with fever and severe abdominal symptoms admitted with concerns for multisystem inflammatory syndrome in children (MIS-C). Laboratory evaluation revealed elevated markers of inflammation, lymphopenia, and increased d-dimers. Imaging studies revealed multifocal airspace disease and ground-glass opacities. SARS-CoV-2 PCR and serologies were negative. All patients reported a history of vaping, prompting E-cigarette, or vaping, product use-associated lung injury (EVALI) diagnosis. MIS-C has overlapping clinical and laboratory features highlighting the added challenge of diagnosing EVALI during the COVID-19 pandemic.

Peer review status:ACCEPTED

11 Nov 2020Submitted to Pediatric Pulmonology
12 Nov 2020Submission Checks Completed
12 Nov 2020Assigned to Editor
13 Nov 2020Reviewer(s) Assigned
28 Dec 2020Review(s) Completed, Editorial Evaluation Pending
28 Dec 2020Editorial Decision: Revise Minor
09 Feb 20211st Revision Received
09 Feb 2021Submission Checks Completed
09 Feb 2021Assigned to Editor
09 Feb 2021Reviewer(s) Assigned
23 Feb 2021Review(s) Completed, Editorial Evaluation Pending
25 Feb 2021Editorial Decision: Revise Minor
17 Mar 20212nd Revision Received
18 Mar 2021Reviewer(s) Assigned
18 Mar 2021Submission Checks Completed
18 Mar 2021Assigned to Editor
19 Apr 2021Review(s) Completed, Editorial Evaluation Pending
30 Apr 2021Editorial Decision: Revise Minor
14 May 20213rd Revision Received
17 May 2021Assigned to Editor
17 May 2021Submission Checks Completed
17 May 2021Reviewer(s) Assigned
02 Jun 2021Review(s) Completed, Editorial Evaluation Pending
09 Jun 2021Editorial Decision: Accept