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Teenage pregnancy as a risk factor for placental abruption: Findings from the prospective Japan Environment and Children’s Study
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  • Hyo Kyozuka,
  • Tsuyoshi Murata,
  • Toma Fukuda,
  • Yuta Endo,
  • Akiko Yamaguchi,
  • Shun Yasuda,
  • Aya Kanno,
  • Akiko Sato,
  • Yuka Ogata,
  • Mitsuaki Hosoya,
  • Seiji Yasumura,
  • Koichi Hashimoto,
  • Hidekazu Nishigori,
  • Keiya Fujimori
Hyo Kyozuka
Fukushima Medical University
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Tsuyoshi Murata
Fukushima Medical University
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Toma Fukuda
Fukushima Medical University
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Yuta Endo
Fukushima Medical University
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Akiko Yamaguchi
Fukushima Medical University
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Shun Yasuda
Fukushima Medical University
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Aya Kanno
Fukushima Medical University
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Akiko Sato
Fukushima Medical University
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Yuka Ogata
Fukushima Medical University
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Mitsuaki Hosoya
Fukushima Medical University
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Seiji Yasumura
Fukushima Medical University
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Koichi Hashimoto
Fukushima Medical University
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Hidekazu Nishigori
Fukushima Medical University
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Keiya Fujimori
Fukushima Medical University
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Abstract

Objective: To examine the effect of maternal age on placental abruption Design: Prospective cohort study Setting: Fifteen regional centers across Japan Population: We identified 94,410 Japanese women (93,994 without placental abruption and 416 with placental abruption) who were recruited in the Japan Environment and Children’s study between January 2011 and March 2014. Methods: Multiple regression models were used to identify whether maternal age (<20 years, 20–24 years, 25–29 years, 30–34 years, and ≥ 35 years) is a risk factor for placental abruption. The analyses were conducted while considering history of placental abruption, assisted reproductive technology, number of previous deliveries, smoking during pregnancy, body mass index before pregnancy, chronic hypertension, and uterine myoma as confounding factors. Main outcome measures: Maternal age as a risk factor for placental abruption Results: Besides advanced maternal age (≥35 years; adjusted odds ratio [aOR]: 1.7, 95% confidence interval [CI]: 1.1–2.5), teenage pregnancy was also a risk factor for placental abruption (aOR: 2.8, 95% CI: 1.2–6.5) when maternal age of 20–24 years was set as a reference. Conclusions: In the Japanese general population, besides advanced maternal age, teenage pregnancy was also a strong risk factor for placental abruption. The maternal age in Japan is changing since recent decades. Therefore, it is important for obstetric care providers to provide proper counseling to young women based on the up-to-date evidences. Funding: The Japan Environment and Children’s Study was funded by the Ministry of the Environment, Japan