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SHORT-TERM EFFECT OF WHEY PROTEIN SUPPLEMENTATION ON THE NUTRITIONAL STATUS AND QUALITY OF LIFE OF PATIENTS WAITING FOR LIVER TRANSPLANTATION
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  • Michelle d’Alessandro,
  • Jéssica Morais,
  • Yani Mizubuti,
  • Thales da Silva,
  • Silvia Fernandes,
  • Larissa Mendes,
  • Maria Isabel Correia,
  • Simone Generoso
Michelle d’Alessandro
Universidade Federal de Minas Gerais
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Jéssica Morais
Universidade Federal de Minas Gerais
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Yani Mizubuti
Universidade Federal de Minas Gerais
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Thales da Silva
Universidade Federal de Minas Gerais
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Silvia Fernandes
Universidade Federal de Minas Gerais
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Larissa Mendes
Universidade Federal de Minas Gerais
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Maria Isabel Correia
Universidade Federal de Minas Gerais
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Simone Generoso
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Abstract

Background & aims: Chronic liver disease is associated with malnutrition that negatively impacts a patient’s health-related quality of life (HRQoL). We evaluated the short-term effect of whey protein supplementation on the HRQoL and nutritional and functional status of patients waiting for liver transplantation (LT). Methods: This was a double-blind randomized clinical trial with patients waiting for LT who were randomized into two groups: WP (whey protein supplementation) and the control (casein supplementation). Both groups received 40g (20g in the morning and 20 g in the evening) for 15 days. Nutritional and functional status were evaluated. Energy balance (EB) was calculated as the difference between energy intake (24-hour recall) and total energy expenditure. The chronic liver disease questionnaire (CLDQ) was used to assess HRQoL. All measurements were performed before and after the intervention. Results: Fifty-six patients were evaluated. Malnutrition was present in 56.9% of patients, and it was directly associated with a poor HRQoL (p<0.05). No improvement on the nutritional and functional status was observed, in either group after protein supplementation. HRQoL improved after WP and casein supplementation, with no differences between groups (p>0.05). Patients who met protein requirements and had a positive EB demonstrated a higher HRQoL score (4.9) (p<0.05), without between-group differences. Conclusion: Malnutrition substantially reduces HRQoL. Short-term WP or casein supplementation improved the HRQoL.