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Late-onset coronary thrombosis and thrombocytosis following G-CSF treatment in a healthy donor: A Case Report
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  • Cheng Xie,
  • Fan Xia,
  • Caiyun Li,
  • Haipeng Wang,
  • Bin Jiang,
  • Mianxian Li,
  • Zexiong Feng
Cheng Xie
The First Affiliated Hospital of Soochow University
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Fan Xia
The First Affiliated Hospital of Soochow University
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Caiyun Li
The Affiliated Suzhou Science and Technology Town Hospital of Nanjing Medical University
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Haipeng Wang
The First Affiliated Hospital of Soochow University
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Bin Jiang
The First Affiliated Hospital of Soochow University
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Mianxian Li
The First Affiliated Hospital of Soochow University
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Zexiong Feng
The First Affiliated Hospital of Soochow University
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Abstract

Granulocyte colony stimulating factor (G-CSF) has been widely used as a mobilizing agent to rapidly increase peripheral blood stem and progenitor cells. Limited data is available for G-CSF-associated late-onset coronary thrombosis and thrombocytosis. We report a case of a 23-year-old Chinese Han patient who presented with acute myocardial infarction and thrombocytosis after finishing bone marrow harvesting and peripheral blood stem cell collection following G-CSF treatment several days later. By using antiplatelet drugs and undergoing percutaneous transluminal coronary angioplasty, the patient’s symptoms were relieved and his platelet level decreased to normal. This is the first suspected case report of late-onset coronary thrombosis and thrombocytosis related to G-CSF. Caution should be taken for the delayed adverse reactions in patients undergoing G-CSF mobilizing.