Based on network pharmacology and molecular docking to explore the
Traditional Chinese Medicine anti-influenza mechanisms:Chinese protocol
for diagnosis and treatment of influenza.
Background Explore the possible mechanism of anti-influenza virus, based
on the study of the active components-drug-target network,
Protein-Protein Interaction (PPI) network and molecular docking
verification, we explored the potential action mechanism of TCM in
Chinese protocol for diagnosis and treatment of influenza 2019. Methods
Screening the active components and potential targets of 12 drugs in the
scheme by using TCMSP database, and Obtaining the target of influenza by
GeneCard, Durgbank, OMIM, TTD and PharmGkb databases. Then, constructed
the “component-durg-target” network and PPI network were by
Cytoscape3.8.0 software. Morethan, analyzed and the biological function
and pathway, verified the molecular docking by AutoDock Vina software.
Results The 12 drugs in the recommended scheme (XBCQ) for severe
influenza contain 192 active components and involve 31 key antiviral
targets, which may play an antiviral role through biological processes
such as lipopolysaccharide, pathogen molecular reaction and regulate
signaling pathway via the IL-17, influenza A, TNF, Toll-like receptors.
Conclusion TCM play critical therapeutic roles through
“multi-components, multi-targets and multi-pathways” mechanisms in
influenza infection. The antiviral pharmacological mechanism of Xuanbai
Chengqi decoction, which was analyzed by network pharmacology and
molecular docking, provide a new idea for further exploring the
diagnosis and treatment of severe influenza.