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Sequence and evolutionary analysis of bacterial ribosomal S1 proteins
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  • Evgenia Deryusheva,
  • Andrey Machulin,
  • Maxim Matyunin,
  • Oxana Galzitskaya
Evgenia Deryusheva
Institute for Biological Instrumentation, Federal Research Center "Pushchino Scientific Center for Biological Research of the Russian Academy of Sciences”
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Andrey Machulin
Institute for Biological Instrumentation, Russian Academy of Sciences
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Maxim Matyunin
3 Institute of Protein Research, Russian Academy of Sciences
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Oxana Galzitskaya
Institute of Protein Research
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Abstract

The multi-domain bacterial S1 protein is the largest and most functionally important ribosomal protein of the 30S subunit, which interacts with both mRNA and proteins. The family of ribosomal S1 proteins differs in the classical sense from a protein with tandem repeats and has a “bead-on-string” organization, where each repeat is folded into a globular domain. Based on our recent data, the study of evolutionary relationships for the bacterial phyla will provide evidence for one of the proposed theories of the evolutionary development of proteins with structural repeats: from multiple repeats of assembles to single repeats, or vice versa. In this comparative analysis of 1333 S1 sequences that were identified in 24 different phyla; we demonstrate how such phyla can independently/dependently form during evolution. To our knowledge, this work is the first study of the evolutionary history of bacterial ribosomal S1 proteins. The collected and structured data can be useful to computer biologists as a resource for determining percent identity, amino acid composition and logo motifs, as well as dN/dS ratio in bacterial S1 protein. The obtained research data suggested that the evolutionary development of bacterial ribosomal proteins S1 evolved from multiple assemblies to single repeat. The presented data are integrated into the server, which can be accessed at http://oka.protres.ru:4200.

Peer review status:ACCEPTED

18 Nov 2020Submitted to PROTEINS: Structure, Function, and Bioinformatics
19 Nov 2020Submission Checks Completed
19 Nov 2020Assigned to Editor
29 Nov 2020Reviewer(s) Assigned
09 Jan 2021Review(s) Completed, Editorial Evaluation Pending
31 Jan 2021Editorial Decision: Revise Major
16 Mar 20211st Revision Received
17 Mar 2021Submission Checks Completed
17 Mar 2021Assigned to Editor
17 Mar 2021Reviewer(s) Assigned
05 Apr 2021Review(s) Completed, Editorial Evaluation Pending
07 Apr 2021Editorial Decision: Accept