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Ventilatory response to CO2 with Read's rebreathing method in normal infants
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  • Yosuke Yamada,
  • Henmi Nobuhide,
  • Hisaya Hasegawa,
  • Shio Tsuruta,
  • Yusuke Suganami,
  • Satoko Tokumasu,
  • Masanori Wasa
Yosuke Yamada
Tokyo Women's Medical University Medical Center East
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Henmi Nobuhide
Tokyo Women's Medical University Medical Center East
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Hisaya Hasegawa
Tokyo Women's Medical University Medical Center East
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Shio Tsuruta
Tokyo Women's Medical University Medical Center East
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Yusuke Suganami
Tokyo Women's Medical University Medical Center East
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Satoko Tokumasu
Tokyo Women's Medical University Medical Center East
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Masanori Wasa
Tokyo Women's Medical University Medical Center East
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Abstract

Background Methods of evaluating the ventilatory response to CO2 (VRCO2) of the respiratory center include the steady-state and the rebreathing method. Although the rebreathing method can evaluate the respiratory center more in detail, the steady-state method has been mainly performed in infants. The aim of this study was to investigate whether we could perform the VRCO2 with the rebreathing method in normal infants. Methods The subjects were 80 normal infants. The gestational age was 39.9(39.3-40.3)weeks, and the birth body weight was 3,142 (2,851-3,451) grams. We performed the VRCO2 with Read’s rebreathing method, measuring the increase in minute volume (MV) in response to the increase in EtCO2 by rebreathing a closed circuit. The value of VRCO2 was calculated as follow: VRCO2 (mL/min/mmHg/kg) = ΔMV / ΔEtCO2 / Body weight. Results We performed the examination without adverse events. The age in days at examination was 3 (2-4), and the examination time was 150±38 seconds. The maximum EtCO2 was 51.1 (50.5-51.9) mmHg. The value of VRCO2 was 34.6 (29.3-42.8). Tidal volume had a greater effect on the increase in MV than respiratory rate (5.4 to 14.3 mL/kg, 44.1 to 55.9 /min, respectively). Conclusion This study suggests that the rebreathing method can evaluate the ventilatory response to high blood CO2 in a short examination time. We conclude that the rebreathing method is useful even in infants. In the future, we plan to measure the VRCO2 of preterm infants, and evaluate the respiratory center of infants in more detail.

Peer review status:ACCEPTED

22 Nov 2020Submitted to Pediatric Pulmonology
23 Nov 2020Submission Checks Completed
23 Nov 2020Assigned to Editor
23 Nov 2020Reviewer(s) Assigned
12 Dec 2020Review(s) Completed, Editorial Evaluation Pending
12 Dec 2020Editorial Decision: Revise Major
23 Feb 20211st Revision Received
23 Feb 2021Submission Checks Completed
23 Feb 2021Assigned to Editor
23 Feb 2021Reviewer(s) Assigned
24 Feb 2021Review(s) Completed, Editorial Evaluation Pending
24 Feb 2021Editorial Decision: Accept