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Animal models of diabetes-associated vascular diseases: An update on available models and experimental analysis
  • Judy Choi,
  • Judy de Haan,
  • Arpeeta Sharma
Judy Choi
Baker Heart and Diabetes Institute
Author Profile
Judy de Haan
Baker Heart and Diabetes Institute
Author Profile
Arpeeta Sharma
Baker Heart and Diabetes Institute
Author Profile

Abstract

Diabetes is a chronic metabolic disorder associated with the accelerated development of macrovascular (atherosclerosis, coronary artery disease) and microvascular complications (nephropathy, retinopathy and neuropathy), which remain the principal cause of mortality and morbidity in this population. Current understanding of cellular and molecular pathways of diabetes-driven vascular complications as well as therapeutic interventions have arisen from studying disease pathogenesis in animal models. Diabetes-associated vascular complications are multi-faceted, involving the interaction between various cellular and molecular pathways. Thus, the choice of an appropriate animal model to study vascular pathogenesis is important in our quest to identify innovative and mechanism-based targeted therapies to reduce the burden of diabetic complications. Herein, we provide up-to-date information on available mouse models of both Type 1 and Type 2 diabetic vascular complications as well as experimental analysis and research outputs.

Peer review status:ACCEPTED

27 Nov 2020Submitted to British Journal of Pharmacology
27 Nov 2020Submission Checks Completed
27 Nov 2020Assigned to Editor
29 Nov 2020Reviewer(s) Assigned
25 Jan 2021Review(s) Completed, Editorial Evaluation Pending
09 Feb 2021Editorial Decision: Revise Minor
05 Mar 20211st Revision Received
11 Mar 2021Submission Checks Completed
11 Mar 2021Assigned to Editor
18 Mar 2021Reviewer(s) Assigned
11 Apr 2021Review(s) Completed, Editorial Evaluation Pending
01 Jun 2021Editorial Decision: Accept