Phytochemicals targeting metabolic reprogramming in cancer: an
assessment of role, mechanisms, pathways and therapeutic relevance
- Asifa Khan,
- Shumaila Siddiqui,
- Syed Husain,
- Sybille Mazurek,
- Mohammad Askandar Iqbal
Shumaila Siddiqui
Jamia Millia Islamia Central University
Author ProfileSybille Mazurek
Justus Liebig University Giessen Institute of Veterinary Physiology and Biochemistry
Author ProfileMohammad Askandar Iqbal
Jamia Millia Islamia Central University
Author ProfileAbstract
The metabolism of cancer is remarkably different from that of normal
cells and confers variety of benefits including the promotion of other
cancer hallmarks. As the rewired metabolism is a near-universal property
of cancer cells, efforts are underway to exploit metabolic
vulnerabilities for therapeutic benefit. In the continued search for a
safer and effective ways of cancer treatment, structurally diverse
plant-based compounds have gained substantial attention. Here, we
present an extensive assessment of the role of phytocompounds in
modulating cancer metabolism and make a case for the use of plant-based
compounds in targeting metabolic vulnerabilities of cancer. We discuss
the interactions of phytocompounds with major metabolic pathways and
evaluate the role of phytochemicals in the regulation of growth
signaling and transcriptional programs involved in metabolic
transformation of cancer. Lastly, we examine the potential of these
compounds in clinical management of cancer along with limitations and
challenges