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TRPA1 in obesity and insulin resistance
  • +1
  • Neha Mahajan,
  • Pragyanshu Khare,
  • Kanthi Kondepudi,
  • Mahendra Bishnoi
Neha Mahajan
National Agri-Food Biotechnology Institute
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Pragyanshu Khare
National Agri-Food Biotechnology Institute
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Kanthi Kondepudi
National Agri-Food Biotechnology Institute
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Mahendra Bishnoi
National Agri-Food Biotechnology Institute
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Abstract

Transient receptor potential ankyrin 1 (TRPA1) channel is a calcium permeable, non-selective cation channel, expressed in the sensory neurons and non-neuronal cells of different tissues. Initially studied for its role in pain and inflammation, TRPA1 has now functionally involved in multiple other physiological functions. TRPA1 channel has been extensively studied for modulation by pungent compounds present in the spices and herbs. In the last decade, the role of TRPA1 agonism in body weight reduction, secretion of hunger and satiety hormones, insulin secretion and thermogenesis, has unveiled the potential of the TRPA1 channel to be used as a preventive target to tackle obesity and associated comorbidities including insulin resistance in type 2 diabetes. In this review, we summarized the recent findings of TRPA1 based dietary/non-dietary modulation for its role in obesity prevention and therapeutics.