Tidal breathing pulmonary function and influencing factors in late
preterm and full-term neonates
Abstract
Neonatal period is the key stage of lung development. However, tidal
breathing pulmonary function (TBPF) of late preterm and full-term
infants without pathology has rarely been studied. Our research focuses
on the early neonatal period and aims to detect the factors influencing
PF and implemente effective interventions earlier. Methods: This
prospective study evaluated the PF characteristics of 142 infants
admitted to our neonatology department. Potential explanatory variables
for TBPF were analyzed using single-factor and multi-factor linear
regression analyses. Results: PF characteristics, including tidal volume
(VT) and minute ventilation (MV), were significantly lower in late
preterm infants compared to full-term infants (P<0.01).
TPTEF/TE and VPTEF/VE were not significantly different between groups
(P>0.05). In the single-factor analysis, changes in
parameters related to lung volume (VT, VT/kg, MV) were mainly correlated
with gestational age (GA), corrected GA, birth weight, weight at
examination, weight changes, and serum albumin(SAB). After birth, VT/kg
and indicators of airway obstruction (VPTEF/VE and TPTEF/TE) changed
significantly with increasing age. In the multiple-factor analysis, the
main factors influencing VT, VT/kg, and MV were corrected GA and daily
weight change, GA and corrected GA, and corrected GA and SAB,
respectively. Conclusion: The main difference in PF between full-term
and late premature infants was the lung volume. In these newborns PF was
associated with GA, corrected GA, daily weight change, and SAB level.
These results suggest that an adequate energy supply is critical for PF
development in neonates, and especially for premature infants.