African swine fever (ASF) has circulated in Viet Nam since 2018, causing
significant loss to the pig industry. The clinical signs of the
ASFV-infected piglets have not been well documented. This is the first
report of neonate piglets with neurological signs. ASFV was detected in
brain tissues by PCRs and IHC. Also, CSF, PPV, PRRSV were not detected
by PCRs suggesting that the ASFV might be the cause of neurological
signs in piglets. It is recommended that brain tissues should be used in
the ASFV detection in piglets, especially in neurological cases.