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Prognostic value of intraductal carcinoma for adjuvant radiotherapy candidates after radical prostatectomy
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  • Sedat Karakoc,
  • Serdar Çelik,
  • Nilhan Akbulut,
  • Ozan Bozkurt,
  • Hulya Ellidokuz,
  • Burçin Tuna,
  • Kutsal Yörükoğlu,
  • Mehmet Uğur Mungan
Sedat Karakoc
Dokuz Eylül University
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Serdar Çelik
Dokuz Eylül University
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Nilhan Akbulut
Dokuz Eylül University
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Ozan Bozkurt
Dokuz Eylül University
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Hulya Ellidokuz
Dokuz Eylül University
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Burçin Tuna
Dokuz Eylül University
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Kutsal Yörükoğlu
Dokuz Eylül University
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Mehmet Uğur Mungan
Dokuz Eylül University
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Abstract

ABSTRACT Objective: We aimed to investigate the prognostic significance of intraductal carcinoma in radical prostatectomy (RP) specimens and predictive value of IDC-P for biochemical recurrence and adjuvant therapy decision. Method: Patients who underwent RP between 2000-2014 with final pathological stage pT3a and negative surgical margins (Group 1, n=35) and pT2 with positive surgical margins (Group 2, n=32) were included. RP specimens were re-evaluated for the presence of IDC-P component and other prognostic factors. In both groups, prognostic factors were compared according to the presence of IDC-P and biochemical recurrence status. Results: In group 1, IDC-P was detected in 5 cases and biochemical recurrence was detected in 3 cases. Patients with IDC-P showed significantly higher biochemical recurrence than those without IDC-P (p=0.002). In univariate analysis, IDC-P was found to be significantly associated with worse progression free survival (p<0.001). In group 2, IDC-P was detected in 4 cases and biochemical recurrence was detected in 10 cases. Also, tumor volume was significantly higher in patients with IDC-P than those without IDC-P (p=0.02). IDC-P was also significantly associated with worse progression free survival in group 2 (p=0.033). Conclusions: In both groups, IDC-P is a prognostic factor for progression free survival and / or biochemical recurrence. Especially in these patients, presence of IDC-P might be helpful for postoperative adjuvant therapy management decision. Keywords: radical prostatectomy, intraductal carcinoma of prostate (IDC-P), prostate cancer, biochemical recurrence, progression free survival.

Peer review status:ACCEPTED

04 Dec 2020Submitted to International Journal of Clinical Practice
07 Dec 2020Submission Checks Completed
07 Dec 2020Assigned to Editor
11 Dec 2020Reviewer(s) Assigned
17 Dec 2020Review(s) Completed, Editorial Evaluation Pending
27 Dec 20201st Revision Received
28 Dec 2020Submission Checks Completed
28 Dec 2020Assigned to Editor
28 Dec 2020Reviewer(s) Assigned
04 Jan 2021Review(s) Completed, Editorial Evaluation Pending
18 Feb 2021Editorial Decision: Accept