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ACUTE MYELOID LEUKAEMIA WITH DOWN SYNDROME: A CASE SERIES ON THE USE OF VINCRISTINE
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  • Gregory Joey,
  • Max Mantik,
  • Stefanus Gunawan,
  • Valerie Haas,
  • Gertjan Kaspers
Gregory Joey
Sam Ratulangi University
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Max Mantik
Sam Ratulangi University
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Stefanus Gunawan
Sam Ratulangi University
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Valerie Haas
Princess Máxima Center for Pediatric Oncology
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Gertjan Kaspers
Princess Maxima Center for Pediatric Oncology
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Abstract

Myeloid Leukemia with Down Syndrome (ML-DS) is a unique entity of AML with superior treatment response and overall survival compared to children with AML. Despite all of it, ML-DS survival rates for children in low- and middle-income countries (LMICs) remain poor. We described three ML-DS cases, which were treated with vincristine, cytarabine and daunorubicin plus triple intrathecal drugs. All of our three patients successfully finished the treatment, with two patients were still complete remission until now, and one died two days after finishing the chemotherapy. ML-DS is treatable in our limited-resources setting in Manado, Indonesia.