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ARIA-EAACI statement on severe allergic reactions to COVID-19 vaccines -- an EAACI-ARIA Position Paper
  • +14
  • Ludger Klimek,
  • Marek Jutel,
  • Cezmi Akdis,
  • Jean Bousquet,
  • Mubeccel Akdis,
  • María José Torres,
  • Ioana Agache,
  • Giorgio Walter Canonica,
  • Stefano R. Del Giacco,
  • Liam O'Mahony,
  • Mohamed Shamji,
  • Ruby Pawankar,
  • Eva Untersmayr,
  • Johannes Ring,
  • Anna Bedbrook,
  • Margitta Worm,
  • Torsten Zuberbier
Ludger Klimek
Zentrum für Rhinologie und Allergologie
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Marek Jutel
Wrocław Medical University
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Cezmi Akdis
University of Zurich
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Jean Bousquet
Université Versailles, St-Quentin-en-Yvelines
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Mubeccel Akdis
University of Zürich
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María José Torres
Universidad de Málaga Facultad de Medicina
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Ioana Agache
Transylvania University of Brasov
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Giorgio Walter Canonica
Humanitas Clinical and Research Center
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Stefano R. Del Giacco
University of Cagliari Faculty of Medicine
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Liam O'Mahony
University College Cork National University of Ireland
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Mohamed Shamji
Imperial College London
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Ruby Pawankar
Nippon Medical School
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Eva Untersmayr
Center of Physiology, Pathophysiology and Immunology
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Johannes Ring
Technische Universitat Munchen
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Anna Bedbrook
Hôpital Arnaud de Villeneuve
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Margitta Worm
Charité - Universitätsmedizin Berlin
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Torsten Zuberbier
Charité Universitätsmedizin Berlin
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Abstract

Coronavirus disease 2019 (COVID-19) vaccine BNT162b2 received approval and within the first few days of public vaccination several severe anaphylaxis cases occurred. An investigation is taking place to understand the cases and their triggers. The vaccine will be administered to a large number of individuals worldwide and concerns raised for severe adverse events might occur. With the current information, the European Academy of Allergy and Clinical Immunology (EAACI) states its position for the following preliminary recommendations that are to be revised as soon as more data emerges. To minimize the risk of severe allergic reactions in vaccinated individuals, it is urgently required to understand the specific nature of the reported severe allergic reactions, including the background medical history of the individuals affected and the mechanisms involved. To achieve this goal all clinical and laboratory information should be collected and reported. Mild and moderate allergic patients should not be excluded from the vaccine as the exclusion of all these patients from vaccination may have a significant impact on reaching the goal of population immunity. Health care practitioners vaccinating against COVID-19 are required to be sufficiently prepared to recognise and treat anaphylaxis properly with the ability to administer adrenaline. A mandatory observation period after vaccine administration of at least 15 minutes for all individuals should be followed. The current guidelines, which exclude patients with severe allergies from vaccination with BNT162b2, should be re-evaluated after more information and experience with the new vaccine develops.

Peer review status:ACCEPTED

23 Dec 2020Submitted to Allergy
23 Dec 2020Assigned to Editor
23 Dec 2020Submission Checks Completed
25 Dec 2020Review(s) Completed, Editorial Evaluation Pending
28 Dec 2020Editorial Decision: Accept