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„CHildhood Allergy and tolerance: bioMarkers and Predictors” (CHAMP) -A call for prediction and quality of life
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  • Jana Eckert,
  • Julia Kahle,
  • Andreas Böck,
  • Kathrin Zeber,
  • Kathrin Urner,
  • Wolfgang Greiner,
  • Simone Kreimeier,
  • Kirsten Beyer,
  • Josefine Dobbertin-Welsch,
  • Eckard Hamelmann,
  • Ines Gellhaus,
  • Christina Schorlemer,
  • Michael Kabesch,
  • Parastoo Kheiroddin,
  • Erika von Mutius,
  • Martin Depner,
  • Daniel Walter,
  • Gesine Hansen,
  • Stephanie DeStefano,
  • Sabine Schnadt,
  • Bianca Schaub
Jana Eckert
Dr von Haunersches Kinderspital Kinderklinik und Kinderpoliklinik der Ludwig Maximilian Universitat Munchen
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Julia Kahle
German Allergy and Asthma Foundation
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Andreas Böck
Dr von Haunersches Kinderspital Kinderklinik und Kinderpoliklinik der Ludwig Maximilian Universitat Munchen
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Kathrin Zeber
Dr von Haunersches Kinderspital Kinderklinik und Kinderpoliklinik der Ludwig Maximilian Universitat Munchen
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Kathrin Urner
Dr von Haunersches Kinderspital Kinderklinik und Kinderpoliklinik der Ludwig Maximilian Universitat Munchen
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Wolfgang Greiner
Bielefeld University
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Simone Kreimeier
Bielefeld University
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Kirsten Beyer
Charite University Hospital Berlin
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Josefine Dobbertin-Welsch
Charite University Hospital Berlin
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Eckard Hamelmann
Bielefeld University
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Ines Gellhaus
Bielefeld University
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Christina Schorlemer
Bielefeld University
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Michael Kabesch
University of Regensburg
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Parastoo Kheiroddin
University of Regensburg
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Erika von Mutius
Dr von Haunersches Kinderspital Kinderklinik und Kinderpoliklinik der Ludwig Maximilian Universitat Munchen
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Martin Depner
Helmholtz Center Munich German Research Center for Environmental Health
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Daniel Walter
Dr von Haunersches Kinderspital Kinderklinik und Kinderpoliklinik der Ludwig Maximilian Universitat Munchen
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Gesine Hansen
Hannover Medical School
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Stephanie DeStefano
Hannover Medical School
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Sabine Schnadt
German Allergy and Asthma Foundation
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Bianca Schaub
Dr von Haunersches Kinderspital Kinderklinik und Kinderpoliklinik der Ludwig Maximilian Universitat Munchen
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Abstract

Background: Allergic diseases are the most prevalent chronic childhood diseases resulting in a massive societal and economic burden for the community and a significant reduction of health-related quality of life (HRQoL) for affected families. The project CHAMP (CHildhood Allergy and tolerance: bioMarkers and Predictors) was funded in 2017 by the German Federal Ministry for Education and Research. Methods: CHAMP investigates the determinants of different allergic diseases from birth to adolescence to identify clinically relevant biomarkers predicting onset, progression, remission and severity. Data on HRQoL and patient’s needs and requirements were collected, supported by the German Asthma and Allergy Association (DAAB). Using validated questionnaires and outpatient visits, eight subprojects analysed allergic diseases in epidemiological or clinical cohorts (more than 2500 children/adolescents), sampling numerous biomaterials to assess omics on several levels. Murine models disentangled underlying mechanisms of early tolerance, translating findings from the cohorts to models and vice versa. Results: The DAAB survey, including 851 participants, showed that 83% were interested in prediction of the course of different current allergic diseases and future manifestation. 86% of participants considered doctor’s specialized training and their education as highly important, over 70% chose research for allergy understanding and prevention as critical. CHAMP addresses these needs. Common SOPs have been established and recruitment is ongoing. Conclusion: The DAAB patient survey confirmed the critical need for translational allergy research. CHAMP envisions to predict onset, tolerance and remission of allergic diseases and to identify disease sub-phenotypes for future development of preventive strategies and novel avenues for therapeutic options.