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Hypoglycemia In The Emergency, But What Awaits Us For Cardiac Risks In The Future?
  • Onur Akhan,
  • İsa Ardahanlı
Onur Akhan
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İsa Ardahanlı
Bilecik Training and Research Hospital
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Introduction: Several homeostatic changes like an increase in sympathoadrenal response and oxidative stress occur in hypoglycemia. As a result of these findings, an increase in inflammation and pre-atherogenic factors is observed and these changes may lead to endothelial dysfunction. Aim: Our study aims to reveal possible cardiac risks (systolic-diastolic functions and endothelial dysfunctions) in patients who have applied to the emergency department with hypoglycemia. Methods: This cross-sectional, case-control study included 46 hypoglycemia patients who admitted to the emergency with symptoms compatible with hypoglycemia and diagnosed with hypoglycemia and 30 healthy volunteers. All patients were evaluated with baseline echocardiography, tissue-doppler imaging(carotid and brachial artery). Also, the fasting blood tests of the patients referred to the internal medicine department were examined. Results: There were no differences between the groups regarding age, weight, body mass index, and systolic blood pressure. Total cholesterol, LDL, HDL, Vitamin B12, TSH, and fasting blood glucose levels were similar in the groups’ blood tests (all p values>0.05). We observed a statistically significant decrease in diastolic dysfunction parameters: E/A and E/e’ ratios (respectively, p=0.020 and 0.026). It was shown that insulin resistance was influential in forming these considerable differences. The patient group observed that the carotid intima-media thickness was more remarkable(p=0.001), and the brachial flow-mediated dilatation value was smaller(p=0.003), giving an idea about endothelial functions.

Peer review status:ACCEPTED

24 Dec 2020Submitted to Echocardiography
24 Dec 2020Submission Checks Completed
24 Dec 2020Assigned to Editor
07 Jan 2021Reviewer(s) Assigned
12 Jan 2021Review(s) Completed, Editorial Evaluation Pending
14 Jan 2021Editorial Decision: Revise Minor
15 Jan 20211st Revision Received
16 Jan 2021Submission Checks Completed
16 Jan 2021Assigned to Editor
16 Jan 2021Reviewer(s) Assigned
16 Jan 2021Review(s) Completed, Editorial Evaluation Pending
18 Jan 2021Editorial Decision: Accept