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Harnessing Pivotal Advances for Production and Structural Derivation of the Promising Molecule Ursolic Acid
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  • Hao-ran Liu,
  • Nadeem Ahmad,
  • Bo Lv,
  • Chun Li
Hao-ran Liu
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Nadeem Ahmad
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Abstract

Ursolic acid (UA) is a ursane-type pentacyclic triterpenoid compound, naturally produced in plants via specialized metabolism and exhibits vast range of remarkable physiological activities and pharmacological manifestations. Owing to significant safety and efficacy in different medical conditions, UA may serve as a backbone to produce its derivatives with novel therapeutic functions. This review systematically provides an overview of the pharmacological activities, acquisition methods and structural modification methods of UA. In addition, we focused on the synthetic modifications of UA to yield its valuable derivatives with enhanced therapeutic potential. Furthermore, harnessing the essential advances for green synthesis of UA and its derivatives by advent of metabolic engineering and synthetic biology are highlighted. In combination with the advantages of UA biosynthesis and transformation strategy, large-scale production and applications of UA is a promising platform for further exploration.

Peer review status:ACCEPTED

31 Dec 2020Submitted to Biotechnology Journal
11 Jan 2021Submission Checks Completed
11 Jan 2021Assigned to Editor
13 Jan 2021Reviewer(s) Assigned
22 Feb 2021Editorial Decision: Revise Major
01 Apr 20211st Revision Received
01 Apr 2021Assigned to Editor
01 Apr 2021Submission Checks Completed
01 Apr 2021Reviewer(s) Assigned
28 Apr 2021Editorial Decision: Revise Minor
03 May 20212nd Revision Received
03 May 2021Submission Checks Completed
03 May 2021Assigned to Editor
03 May 2021Reviewer(s) Assigned
11 May 2021Editorial Decision: Revise Minor
16 May 20213rd Revision Received
17 May 2021Assigned to Editor
17 May 2021Submission Checks Completed
18 May 2021Editorial Decision: Accept