Factors associated with suggestive of pulmonary hypertension measured by
echocardiography in patients with a mediastinal tumor: A single-center
study
Abstract
Background: Ultrasound techniques are generally not used as a primary
tool in the evaluation of mediastinal tumors and cysts. This study aimed
to identify factors associated with pulmonary hypertension (PH) measured
by transthoracic echocardiography (TTE) in patients with a mediastinal
tumor. Methods: This retrospective, observational study was performed
from January 2015 to December 2020. Fifty-five patients (mean age, 62 ±
13 years; 31 [56%] women) who had a mediastinal tumor and underwent
TTE were included. Patients were classified as with PH or without PH. We
analyzed clinical factors and echocardiographic parameters. Results: PH
was found in 21 (38%) patients. Twenty-two patients were asymptomatic,
and none had symptoms associated with PH. Forty-seven (86%) patients
underwent surgery, and 23 (42%) patients were diagnosed with malignant
tumors. The presence of PH was not related with malignancy. Patients
with PH were older than those without PH (67 ± 10 versus [vs.] 59 ±
14 years, p = 0.017). Small left ventricular (LV) systolic dimension
(29.4 ± 3.6 vs. 31.6 ± 3.6 mm, p = 0.040) and dimension (4.2 ± 0.3 vs.
4.5 ± 0.3 mm, p = 0.004) and hyperdynamic LV ejection fraction (EF, 69 ±
6 vs. 65 ± 5%, p = 0.019) were associated with PH. Among them, older
age, small LV dimension, and high EF were independently associated with
PH. Conclusion: The presence of PH had no significant effect on
patients’ clinical manifestation or malignancy.