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A Multicenter Study of Three-dimensional Echocardiographic Evaluation of Normal Pediatric Left Ventricular Volumes and Function
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  • Pei-Ni Jone,
  • Lisa Le,
  • Zhaoxing Pan,
  • Tim Colen,
  • Sachie Shigemitsu,
  • Nee Scze Khoo,
  • Benjamin Goot,
  • Anitha Parthiban,
  • David Harrild,
  • Alessandra Ferraro,
  • Gerald Marx
Pei-Ni Jone
Children's Hospital Colorado
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Lisa Le
Children's Hospital Colorado
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Zhaoxing Pan
University of Colorado Denver Children's Hospital Colorado Research Institute
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Tim Colen
Stollery Children's Hospital
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Sachie Shigemitsu
Stollery Children's Hospital
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Nee Scze Khoo
Stollery Children's Hospital
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Benjamin Goot
Medical College of Wisconsin
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Anitha Parthiban
Children's Mercy Hospitals and Clinics
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David Harrild
Boston Children's Hospital
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Alessandra Ferraro
Boston Children s Hospital
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Gerald Marx
Boston Children's Hospital
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Abstract

Background: Three-dimensional echocardiography (3DE) evaluation of left ventricular (LV) volume and function in pediatrics compares favorably with cardiac magnetic resonance imaging. The aim of this study was to establish from a multicenter, normal pediatric z-score values of 3DE left ventricular volumes and function. Methods: Six hundred and ninety-eight healthy children (ages 0 to 18 years) were recruited from five centers. LV 3DE was acquired from the 4-chamber view. A vendor independent software analyzed end-diastolic volume (EDV), end-systolic volume (ESV), stroke volume (SV), and ejection fraction (EF) using semi-automated quantification. Body surface area (BSA) based z-scores were generated. Intraobserver and interobserver variability were calculated using intraclass correlation (ICC) and repeatability coefficient (RC). Results: Z-scores were generated for ESV, EDV, and SV. The ICC for intraobserver variability for EDV, ESV, and SV were 0.99, 0.99, and 0.99 respectively. The ICC for interobserver variability for EDV, ESV, and SV were 0.98, 0.94, and 0.98 respectively. The RC for intraobserver and interobserver variability for LV EF was 4.39% (95% CI: 3.01, 5.59) and interobserver was 7.08% (95%CI: 5.51, 8.42). Conclusions: We report pediatric Z-scores for normal LV volumes using the semi-automated method from five centers, enhancing its generalizability. 3DE evaluation of LV volumes and EF in pediatric patients is highly reproducible.

Peer review status:ACCEPTED

18 Jan 2021Submitted to Echocardiography
19 Jan 2021Assigned to Editor
19 Jan 2021Submission Checks Completed
20 Jan 2021Reviewer(s) Assigned
23 Feb 2021Editorial Decision: Accept