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Unboxing mutations: Connecting mutation types with evolutionary consequences
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  • Emma Berdan,
  • Alexandre Blanckaert,
  • Tanja Slotte,
  • Alexander Suh,
  • Anja Westram,
  • Inês Fragata
Emma Berdan
Museum fur Naturkunde - Leibniz-Institut fur Evolutions- und Biodiversitatsforschung
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Alexandre Blanckaert
Instituto Gulbenkian de Ciencia
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Tanja Slotte
Stockholm University
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Alexander Suh
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Anja Westram
IST Austria
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Inês Fragata
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Abstract

A key step in understanding the genetic basis of different evolutionary outcomes (e.g., adaptation) is to determine the roles played by different mutation types. To do this we must simultaneously consider different mutation types in an evolutionary framework. Here we propose a research framework that directly utilizes the most important characteristics of mutations, their population genetic effects, to determine their relative evolutionary significance. We review known population genetic effects of different mutation types and show how these may be connected to different evolutionary outcomes. We provide examples of how to implement this framework and pinpoint areas where more data, theory and synthesis are needed. Linking experimental and theoretical approaches to examine different mutation types simultaneously is a critical step towards understanding their evolutionary significance.

Peer review status:ACCEPTED

14 Jan 2021Submitted to Molecular Ecology
15 Jan 2021Submission Checks Completed
15 Jan 2021Assigned to Editor
25 Jan 2021Reviewer(s) Assigned
03 Mar 2021Review(s) Completed, Editorial Evaluation Pending
03 Mar 2021Editorial Decision: Revise Minor
30 Mar 2021Review(s) Completed, Editorial Evaluation Pending
30 Mar 20211st Revision Received
20 Apr 2021Editorial Decision: Accept