Hemoglobin S (HBS) and hemoglobin E (HBE) are common hemoglobinopathies,
but combined heterozygosity of HBS and HBE (HBSE) is relatively a rare
disease. Most reports suggest that HBSE is generally benign condition.
In this report we describe a 17-year-old male patient presenting with
acute chest syndrome treated with exchange transfusion.