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Richter’s Transformation as leptomeningeal infiltration in a Chronic Lymphocytic Leukemia patient receiving Venetoclax. Could blood-brain barrier be a disease “sanctuary” during Venetoclax treatment?
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  • Maria Dimou,
  • Aikaterini Bitsani,
  • Maria Roumelioti,
  • Aglaia Dimitrakopoulou,
  • Theodoros Iliakis,
  • Vasileios Pardalis,
  • Ioannis Grafakos,
  • Sotiria Kalyva,
  • Athanasios Markopoulos,
  • Marie-Christine Kyrtsonis,
  • Panayiotis Panayiotidis
Maria Dimou
Laiko General Hospital
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Aikaterini Bitsani
Laiko General Hospital
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Maria Roumelioti
Laiko General Hospital
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Aglaia Dimitrakopoulou
Laiko General Hospital
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Theodoros Iliakis
Laiko General Hospital
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Vasileios Pardalis
Laiko General Hospital
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Ioannis Grafakos
Laiko General Hospital
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Sotiria Kalyva
Laiko General Hospital
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Athanasios Markopoulos
Laiko General Hospital
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Marie-Christine Kyrtsonis
Laiko General Hospital
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Panayiotis Panayiotidis
Laiko General Hospital
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Abstract

We present a unique Richter's transformation case in CNS with identical to CLL clonal origin in a patient treated with Venetoclax. With our case we make implications on whether Venetoclax penetrates the blood-brain barrier and we address the debating issue of the appropriate Venetoclax dose in case of drug-drug interactions.

Peer review status:ACCEPTED

09 Jan 2021Submitted to Clinical Case Reports
11 Jan 2021Assigned to Editor
11 Jan 2021Submission Checks Completed
26 Jan 2021Reviewer(s) Assigned
16 Feb 2021Review(s) Completed, Editorial Evaluation Pending
16 Feb 2021Editorial Decision: Accept