Richter’s Transformation as leptomeningeal infiltration in a Chronic
Lymphocytic Leukemia patient receiving Venetoclax. Could blood-brain
barrier be a disease “sanctuary” during Venetoclax treatment?
- Maria Dimou
, - Aikaterini Bitsani,
- Maria Roumelioti,
- Aglaia Dimitrakopoulou,
- Theodoros Iliakis,
- Vasileios Pardalis,
- Ioannis Grafakos,
- Sotiria Kalyva,
- Athanasios Markopoulos,
- Marie-Christine Kyrtsonis,
- Panayiotis Panayiotidis
Abstract
We present a unique Richter's transformation case in CNS with identical
to CLL clonal origin in a patient treated with Venetoclax. With our case
we make implications on whether Venetoclax penetrates the blood-brain
barrier and we address the debating issue of the appropriate Venetoclax
dose in case of drug-drug interactions.09 Jan 2021Submitted to Clinical Case Reports 11 Jan 2021Assigned to Editor
11 Jan 2021Submission Checks Completed
26 Jan 2021Reviewer(s) Assigned
16 Feb 2021Review(s) Completed, Editorial Evaluation Pending
16 Feb 2021Editorial Decision: Accept
